Green Tea Hp

Effects of Green Tea and EGCG on Cardiovascular and Metabolic Health – http://www.jacn.org/cgi/content/abstract/26/4/373S

A Catechin-rich Beverage Improves Obesity and Blood Glucose Control in Patients with Type 2 Diabetes. Tomonori et al. Obesity (2008) 17, 310–317.

We investigated the effects of continuous ingestion of a catechin-rich beverage in patients with type 2 diabetes who were not receiving insulin (Ins) therapy in a double-blind controlled study. The participants ingested green tea containing either 582.8 mg of catechins (catechin group; n = 23) or 96.3 mg of catechins (control group; n = 20) per day for 12 weeks. At week 12, the decrease in waist circumference was significantly greater in the catechin group than in the control group. Adiponectin, which is negatively correlated with visceral adiposity, increased significantly only in the catechin group. Although the increase in Ins at week 12 was significantly greater in the catechin group than in the control group, no apparent difference was noted between the two groups in glucose and hemoglobin A1c. In patients treated with insulinotropic agents, the increase in Ins at week 12 was significantly greater in the catechin group than in the control group. This significant increase in Ins levels was observed only in the catechin group. In the catechin group receiving other treatments, Ins levels remained unchanged. In addition, in patients treated with insulinotropic agents, the decrease in hemoglobin A1c at week 12 was significantly greater in the catechin group than in the control group. These results suggest that a catechin-rich beverage might have several therapeutic uses: in the prevention of obesity; in the recovery of Ins-secretory ability; and, as a way to maintain low hemoglobin A1c levels in type 2 diabetic patients who do not yet require Ins therapy.

“The accumulation of thirty minutes of daily activity in addition to making healthy dietary choices can result in slow but steady changes in general wellness. For those who are type II diabetic or at risk of type II diabetes, adding more than 400 mg of EGCG per day can have a therapeutic affect! The changes noted from this study suggest a significant difference in insulin needs for at risk and current diabetics. Simple consistent changes lead to great differences over time.” – Josh Smith

A Catechin-rich Beverage Improves Obesity and Blood Glucose Control in Patients with Type 2 Diabetes. Tomonori et al. Obesity (2008) 17, 310–317.

We investigated the effects of continuous ingestion of a catechin-rich beverage in patients with type 2 diabetes who were not receiving insulin (Ins) therapy in a double-blind controlled study. The participants ingested green tea containing either 582.8 mg of catechins (catechin group; n = 23) or 96.3 mg of catechins (control group; n = 20) per day for 12 weeks. At week 12, the decrease in waist circumference was significantly greater in the catechin group than in the control group. Adiponectin, which is negatively correlated with visceral adiposity, increased significantly only in the catechin group. Although the increase in Ins at week 12 was significantly greater in the catechin group than in the control group, no apparent difference was noted between the two groups in glucose and hemoglobin A1c. In patients treated with insulinotropic agents, the increase in Ins at week 12 was significantly greater in the catechin group than in the control group. This significant increase in Ins levels was observed only in the catechin group. In the catechin group receiving other treatments, Ins levels remained unchanged. In addition, in patients treated with insulinotropic agents, the decrease in hemoglobin A1c at week 12 was significantly greater in the catechin group than in the control group. These results suggest that a catechin-rich beverage might have several therapeutic uses: in the prevention of obesity; in the recovery of Ins-secretory ability; and, as a way to maintain low hemoglobin A1c levels in type 2 diabetic patients who do not yet require Ins therapy.

“The accumulation of thirty minutes of daily activity in addition to making healthy dietary choices can result in slow but steady changes in general wellness. For those who are type II diabetic or at risk of type II diabetes, adding more than 400 mg of EGCG per day can have a therapeutic affect! The changes noted from this study suggest a significant difference in insulin needs for at risk and current diabetics. Simple consistent changes lead to great differences over time.” – Josh Smith

Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation

WESTERTERP-PLANTENGA, MARGRIET S.,MANUELA P.G.M. LEJEUNE, AND EVA M. R. KOVACS.  Obes Res. 2005;13:1195–1204.

Abstract:  Investigation of the effect of a green tea-caffeine mixture on weight maintenance after body weight loss in moderately obese subjects in relation to habitual caffeine intake.Research Methods and Procedures: A randomized placebo- controlled double blind parallel trial in 76 overweight and moderately obese subjects, (BMI, 27.5 _ 2.7 kg/m2) matched for sex, age, BMI, height, body mass, and habitual caffeine intake was conducted. A very low energy diet intervention during 4 weeks was followed by 3 months of weight maintenance (WM); during the WM period, the subjects received a green tea-caffeine mixture (270 mg epigallocatechin gallate _ 150 mg caffeine per day) or placebo. Results: Subjects lost 5.9 _1.8 (SD) kg (7.0 _ 2.1%) of body weight (p _ 0.001). At baseline, satiety was positively,and in women, leptin was inversely, related to subjects’ habitual caffeine consumption (p _ 0.01). High caffeine consumers reduced weight, fat mass, and waist circumference more than low caffeine consumers; resting energy expenditure was reduced less and respiratory quotient was reduced more during weight loss (p _ 0.01). In the low caffeine consumers, during WM, green tea still reduced body weight, waist, respiratory quotient and body fat,whereas resting energy expenditure was increased compared with a restoration of these variables with placebo (p _0.01). In the high caffeine consumers, no effects of the green tea-caffeine mixture were observed during WM. Discussion: High caffeine intake was associated with weight loss through thermogenesis and fat oxidation and with suppressed leptin in women. In habitual low caffeine consumers, the green tea-caffeine mixture improved WM, partly through thermogenesis and fat oxidation.

“Regular consumption of green tea provides a thermogenic affect for weight loss and weight maintenance.  A highlight from this study is the evidence of the use of EGCG as a thermogenic aid.  A thermogenic aid is something that wastes energy in the form of heat, instead of producing energy for the body.  The key to long term success with body weight is having a plan to maintain the progress we make through diet and exercise!” - Josh Smith

It has arrived, Raspberry Cream GreenTeaHP! —- http://bit.ly/2×5Ww6

The magic of green tea…. http://tiny.cc/K0UP9

Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase. Biochemical and Biophysical Research Communications. Volume 338, Issue 2, 16 December 2005, Pages 694-699

Abstract

Phytochemicals such as soy isoflavone genistein have been reported to possess therapeutic effects for obesity, diabetes, and cardiovascular diseases. In the present study, the molecular basis of selective phytochemicals with emphasis on their ability to control intracellular signaling cascades of AMP-activated kinase (AMPK) responsible for the inhibition of adipogenesis was investigated. Recently, the evolutionarily conserved serine/threonine kinase, AMPK, emerges as a possible target molecule of anti-obesity. Hypothalamic AMPK was found to integrate nutritional and hormonal signals modulating feeding behavior and energy expenditure. We have investigated the effects of genistein, EGCG, and capsaicin on adipocyte differentiation in relation to AMPK activation in 3T3-L1 cells. Genistein (20–200 μM) significantly inhibited the process of adipocyte differentiation and led to apoptosis of mature adipocytes. Genistein, EGCG, and capsaicin stimulated the intracellular ROS release, which activated AMPK rapidly. We suggest that AMPK is a novel and critical component of both inhibition of adipocyte differentiation and apoptosis of mature adipocytes by genistein or EGCG or capsaicin further implying AMPK as a prime target of obesity control.

“When you dive into the details of this study, you’ll find that EGCG, a naturally occurring molecule, activates AMPK.  What does all of this mean?  AMPK plays an important role in energy production and more specifically in burning fat as a fuel source, particularly during exercise.  Getting the proper amount of EGCG from green tea will provide this benefit.  30 minutes before your workout you want something to tip the scales in the direction of burning fat more directly.  Consuming naturally occurring molecules, like EGCG, can begin to target mechanisms in your body to turn your fat burning switch to ‘on’!”  – Josh Smith

Targeting Multiple Neurodegenerative Diseases Etiologies with Multimodal-Acting Green Tea Catechins  J. Nutr. 138: 1578S–1583S, 2008.

Silvia A. Mandel,* Tamar Amit, Limor Kalfon, Lydia Reznichenko, and Moussa B. H. Youdim Eve Topf

Abstract

Green tea is currently considered a source of dietary constituents endowed with biological and pharmacological activities relevant to human health. Human epidemiological and new animal data suggest that the pharmacological benefits of tea drinking may help to protect the brain as we age. Indeed, tea consumption is inversely correlated with the incidence of dementia and Alzheimer’s and Parkinson’s diseases. In particular, its main catechin polyphenol constituent (2)-epigallocatechin-3-gallate has been shown to exert neuroprotective/neurorescue activities in a wide array of cellular and animal models of neurological disorders. The intense efforts dedicated in recent years to shed light on the molecular mechanisms participating in the brain protective action of green tea indicate that in addition to the known antioxidant activity of catechins, the modulation of signal transduction pathways, cell survival/death genes, and mitochondrial function all contribute significantly to the induction of neuron viability. Because of the multietiological character of neurodegenerative disease pathology, these natural compounds are receiving significant attention as therapeutic cytoprotective agents that simultaneously manipulate multiple desired targets in the central nervous system. This article elaborates on the multimodal activities of green tea polyphenols with emphasis on their recently described neurorescue/neuroregenerative and mitochondrial stabilization actions.

“The primary focus of this study was accomplished in vitro and animal models, but has since recieved funding from the Micheal J. Fox foundation to have a double blind clinical trial performed.  The results of this study suggest that as little as 3 cups of green tea each day can have a protective effect on brain cells and nerves.  A prospective cohort study followed 30,000 Finnish adults for 13 years to obtain further data.  This is truly a powerful study due to size and results.”   – Josh Smith

Jane V. Higdon and Balz Frei*Linus Pauling Institute, Oregon State University, Corvallis, OR 97331

 ABSTRACT: Increasing interest in the health benefits of tea has led to the inclusion of tea extracts in dietary supplements and functional foods. However, epidemiologic evidence regarding the effects of tea consumption on cancer and cardiovascular disease risk is conflicting. While tea contains a number of bioactive chemicals, it is particularly rich in catechins, of which epigallocatechin gallate (EGCG) is the most abundant. Catechins and their derivatives are thought to contribute to the beneficial effects ascribed to tea. Tea catechins and polyphenols are effective scavengers of reactive oxygen species in vitro and may also function indirectly as antioxidants through their effects on transcription factors and enzyme activities. The fact that catechins are rapidly and extensively metabolized emphasizes the importance of demonstrating their antioxidant activity in vivo. In humans, modest transient increases in plasma antioxidant capacity have been demonstrated following the consumption of tea and green tea catechins. The effects of tea and green tea catechins on biomarkers of oxidative stress, especially oxidative DNA damage, appear very promising in animal models, but data on biomarkers of in vivo oxidative stress in humans are limited. Larger human studies examining the effects of tea and tea catechin intake on biomarkers of oxidative damage to lipids, proteins, and DNA are needed. 

“This study was a compilation of about one-hundred different studies that have investigated the general health benefits of EGCG from green tea.  The amount of data compiled from all these sources have indicated a benefit when consuming 100-200 mg EGCG per day and even more benefit to consuming 400 mg EGCG per day.  Getting the right amount is paramount to the benefits for general health.” – Josh Smith

Five cups of green tea a day lowers cancer risk….. http://tiny.cc/qrLao